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Ships within 48 hours · Estimated delivery Jul 6 - Jul 11
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Description
HPV16 E7 Recombinant Rabbit mAb (SDT-1377-82)Product Specification Host Rabbit Antigen HPV16 E7 Immunogen Recombinant Protein Clone Number SDT 1377 82 Antibody Type Recombinant mAb Isotype IgG Application Sandwich ELISA Purification Protein A Concentration 2 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS pH7. 4, 0. 03% Proclin 300 Stability & Storage 12 months from date of receipt reconstitution, 2 to 8 C as supplied Background HPV16 E7 is a 98 amino acid key
Product Specification
| Host | Rabbit |
| Antigen | HPV16 E7 |
| Immunogen | Recombinant Protein |
| Clone Number | SDT-1377-82 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | Sandwich ELISA |
| Purification | Protein A |
| Concentration | 2 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Background
HPV16 E7 is a 98-amino acid key oncoprotein of human papillomavirus (HPV) type 16; via its conserved CR1/CR2 motifs it binds the retinoblastoma tumor suppressor pRb and related pocket proteins, displacing E2F transcription factors and forcing the infected epithelial cell into S-phase, leading to cell cycle deregulation and unregulated abnormal proliferation. And E7 protein can further enhance the malignant phenotype of cells by binding to other cell cycle inhibitory proteins such as p21 and p27, or activating signaling pathways that promote cell survival and migration, such as PI3K/Akt and MAPK. It also inhibits the normal death of damaged cells, accumulates mutations, and drives the occurrence and progression of HPV-related cancers.
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