SDF1/CXCL12 Recombinant Rabbit mAb, PBS Only (SDT-3675)
SKU: 2889091493

SDF1/CXCL12 Recombinant Rabbit mAb, PBS Only (SDT-3675)

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Description

SDF1/CXCL12 Recombinant Rabbit mAb, PBS Only (SDT-3675)Product Specification Host Rabbit Antigen SDF1 CXCL12 Synonyms Stromal cell derived factor 1; SDF 1; hSDF 1; C X C motif chemokine 12; Intercrine reduced in hepatomas (IRH; hIRH); Pre B cell growth stimulating factor (PBSF); SDF1A; SDF1B Location Secreted Accession P48061 Clone Number SDT 3675 Antibody Type Recombinant mAb Isotype IgG Application IHC P Reactivity Hu Purification Protein A Concentration 1mg ml Conjugation Unconjugated Physical

Product Specification


Host Rabbit
Antigen SDF1/CXCL12
Synonyms Stromal cell-derived factor 1; SDF-1; hSDF-1; C-X-C motif chemokine 12; Intercrine reduced in hepatomas (IRH; hIRH); Pre-B cell growth-stimulating factor (PBSF); SDF1A; SDF1B
Location Secreted
Accession P48061
Clone Number SDT-3675
Antibody Type Recombinant mAb
Isotype IgG
Application IHC-P
Reactivity Hu
Purification Protein A
Concentration 1mg/ml
Conjugation Unconjugated
Physical Appearance Liquid
Storage Buffer

PBS
Stability & Storage

12 months from date of receipt / reconstitution, 4 °C as supplied

Dilution


application dilution species
IHC-P 1:250 Hu

Background

Stromal cell-derived factor-1 (SDF-1), also designated CXCL12, is a 67-amino-acid constitutively secreted chemokine that signals exclusively through the Gαi-protein-coupled receptor CXCR4 (and atypical CXCR7) to orchestrate embryonic development, adult stem-cell homing, immune surveillance, vascular remodeling, and neural circuitry; its 3-stranded β-sheet flanked by an α-helix and disulfide-stabilized loops binds CXCR4 with nanomolar affinity, triggering PI3K–Akt, MAPK/ERK, and calcium flux that mediate chemotaxis, survival, and proliferation, whereas dysregulated SDF-1/CXCR4 signaling fuels cancer metastasis, inflammatory disease, and HIV entry, making the pathway a prime target for small-molecule antagonists, peptide analogs, and neutralizing antibodies in oncology and regenerative medicine.

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SKU: 2889091493

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4.4 ★★★★★
Based on 2386 reviews
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Product Reviews
A
Verified Purchase
Amanda
Carnegie, US
★★★★★ 5
Wow. Just wow. An amazing read
Format: Kindle
This book was eloquently written, or should I say the authors writing style is very eloquent? I loved the characters, and the story was quite compelling. I absolutely loved the FMC, she's a BA who doesn't take any crap & gives as good as she gets. A certain person certainly got his just desserts & then some, the earlier scenes of which were quite satisfying, had me punching the air & everything haha. All in all 20/10, great read
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on November 29, 2024
L
Verified Purchase
Lauren
Houston, US
★★★★★ 3
My opinion
Format: Kindle
Let me preface this by saying I really liked the story and the characters however, this book is in desperate need of some sort of editing. It's not misspelled words or formatting, but continuous run on sentences. Redundancies within the sentences. There were a couple of paragraphs that I had to go back and reread 3 or 4 times. Overall, I'd say it was worth the read.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on May 29, 2025
A
Verified Purchase
Amazon Customer
Birmingham, US
★★★★★ 5
Beautiful
Format: Kindle
I love omegaverses I had looked at this one multiple times thinking it's just another book about cocky rock star guys that let fame get to their heads and there are parts like that so I wasn't 100% off. I started reading the second book and met the fmc Astraea from the first one,after she had a run in with the aphla from the gym.😁 it gave me the push to stop and read book one first and im so glad I did this book was amazing their was so many characters I fell in love with hoping they will find their happily ever after. the guys were great, the plot was 🎯, and the ending had me 😭😭😭. I was wondering how nate could ever redeem himself, and he did. the last scene with him was sad, but I also felt it was beautiful. thank you to the author for making a beautiful omegaverse book that gave me all the feels. now I'm jumping straight into book two.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on March 25, 2025
E
Verified Purchase
E
Carnegie, US
★★★★★ 4
Knot their Omega
Format: Kindle
It took me a day to really get into the book, there is a lot happening in the beginning of the story. I wish there was more of a time frame because I felt like something’s happened quickly but they were farther away than I thought so that was a little confusing to me. I felt like there was so much happening but also not enough. As for the story itself I enjoyed it, it was different than other OV I’ve read. Bring the tissues, you will need them. They guys were great, I wish we saw more of Kai and Kenjis relationship. As for Nate…… IYKYK. I enjoyed this book, my first from this author and look forward to reading about Kamaris story. Book: ⭐️⭐️⭐️⭐️/5 Spice: 🌶️.5/5
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Reviewed in the United States on October 24, 2024
M
Verified Purchase
M. Schmitz
Chelsea, US
★★★★★ 2
Has Potential, Poorly Executed
Format: Kindle
I really really wanted to enjoy this book and was looking forward to reading it. However there were just one too many convoluted plot points, sentences just did not flow nicely at times, and I was left with a lot of confusion on my end. I think it has the bones of being a great story but seems like it was rushed and I had to push myself to finish the last of the book and was left with an unsatisfying ending. It’s definitely different from other omegaverse novels I’ve read but not for good reasons. I really think it could be great but needs some serious tweaking and editing before I’d read it again.
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Reviewed in the United States on February 3, 2025

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