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Description
GCLM Recombinant Rabbit mAb (S-2209-19)Product Specification Host Rabbit Antigen GCLM Synonyms Glutamate cysteine ligase regulatory subunit; GCS light chain; Gamma ECS regulatory subunit; Gamma glutamylcysteine synthetase regulatory subunit; Glutamate cysteine ligase modifier subunit; GLCLR Immunogen Synthetic Peptide Location Cytoplasm Accession P48507 Clone Number S 2209 19 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P, ICC Reactivity Hu, Ms, Rt, Mk Positive Sample
Product Specification
| Host | Rabbit |
| Antigen | GCLM |
| Synonyms | Glutamate--cysteine ligase regulatory subunit; GCS light chain; Gamma-ECS regulatory subunit; Gamma-glutamylcysteine synthetase regulatory subunit; Glutamate--cysteine ligase modifier subunit; GLCLR |
| Immunogen | Synthetic Peptide |
| Location | Cytoplasm |
| Accession | P48507 |
| Clone Number | S-2209-19 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P, ICC |
| Reactivity | Hu, Ms, Rt, Mk |
| Positive Sample | HeLa, A431, HepG2, K562, A549, NIH/3T3, mouse liver, PC-12, rat liver, COS-7 |
| Predicted Reactivity | Bv |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000-1:5000 | Hu, Ms, Rt, Mk |
| IHC-P | 1:200-1:1000 | Hu, Ms, Rt |
| ICC | 1:500 | Hu |
Background
GCLM (glutamate-cysteine ligase modifier subunit) is the regulatory component of glutamate-cysteine ligase (GCL), the rate-limiting enzyme in glutathione biosynthesis; by forming a heterodimer with the catalytic GCLC subunit, GCLM increases the enzyme’s affinity for glutamate and ATP, raises its Ki for glutathione feedback inhibition, and thus accelerates production of the antioxidant glutathione that maintains cellular redox balance and protects against oxidative stress.
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