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Description
SCARB2/LIMPII Recombinant Rabbit mAb (S-2847-21)Product Specification Host Rabbit Antigen SCARB2 LIMPII Synonyms Lysosome membrane protein 2; 85 kDa lysosomal membrane sialoglycoprotein (LGP85); CD36 antigen like 2; Lysosome membrane protein II (LIMP II); Scavenger receptor class B member 2; CD36; CD36L2; LIMP2 Immunogen Synthetic Peptide Location Lysosome Accession Q14108 Clone Number S 2847 21 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P, ICC Reactivity Hu, Mk Positive Sample
Product Specification
| Host | Rabbit |
| Antigen | SCARB2/LIMPII |
| Synonyms | Lysosome membrane protein 2; 85 kDa lysosomal membrane sialoglycoprotein (LGP85); CD36 antigen-like 2; Lysosome membrane protein II (LIMP II); Scavenger receptor class B member 2; CD36; CD36L2; LIMP2 |
| Immunogen | Synthetic Peptide |
| Location | Lysosome |
| Accession | Q14108 |
| Clone Number | S-2847-21 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P, ICC |
| Reactivity | Hu, Mk |
| Positive Sample | SH-SY5Y, HT-29, HeLa, HepG2, COS-7 |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu, Mk |
| IHC-P | 1:1000 | Hu |
| ICC | 1:100 | Hu |
Background
SCARB2/LIMPII, also called lysosomal integral membrane protein-2 (LIMP-2), is an ~85 kDa heavily glycosylated type-III multi-pass membrane protein that resides predominantly in the limiting membranes of lysosomes and late endosomes in every mammalian tissue, where it functions as the mannose-6-phosphate-independent trafficking receptor that escorts the lipid-catabolizing enzyme β-glucocerebrosidase (GBA) from the Golgi to the lysosome lumen, and also serves as the primary cell-surface receptor for enterovirus 71 and several coxsackieviruses that cause hand-foot-and-mouth disease, while genetic loss-of-function mutations in SCARB2 produce the autosomal-recessive “action myoclonus–renal failure syndrome” characterized by progressive myoclonic epilepsy, renal glomerulosclerosis, deafness and peripheral neuropathy.
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