PLK1 Recombinant Rabbit mAb (S-2835-32)
SKU: 47298270151

PLK1 Recombinant Rabbit mAb (S-2835-32)

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Description

PLK1 Recombinant Rabbit mAb (S-2835-32)Product Specification Host Rabbit Antigen PLK1 Synonyms Serine threonine protein kinase PLK1; Polo like kinase 1 (PLK 1); Serine threonine protein kinase 13 (STPK13); PLK Immunogen Synthetic Peptide Location Cytoplasm, Cytoskeleton, Nucleus Accession P53350 Clone Number S 2835 32 Antibody Type Recombinant mAb Isotype IgG Application WB, ICC Reactivity Hu, Ms, Rt, Mk Positive Sample Ramos, HepG2, HeLa, HEK 293, Jurkat, mouse testis, PC 12, rat testis,

Product Specification


Host Rabbit
Antigen PLK1
Synonyms Serine/threonine-protein kinase PLK1; Polo-like kinase 1 (PLK-1); Serine/threonine-protein kinase 13 (STPK13); PLK
Immunogen Synthetic Peptide
Location Cytoplasm, Cytoskeleton, Nucleus
Accession P53350
Clone Number S-2835-32
Antibody Type Recombinant mAb
Isotype IgG
Application WB, ICC
Reactivity Hu, Ms, Rt, Mk
Positive Sample Ramos, HepG2, HeLa, HEK-293, Jurkat, mouse testis, PC-12, rat testis, COS-7
Purification Protein A
Concentration 0.5 mg/ml
Conjugation Unconjugated
Physical Appearance Liquid
Storage Buffer

PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300
Stability & Storage

12 months from date of receipt / reconstitution, -20 °C as supplied

Dilution


application dilution species
WB 1:1000 Hu, Ms, Rt, Mk
ICC 1:500 Hu

Background

PLK1 (Polo-like kinase 1) is a 603-residue serine/threonine kinase that peaks in late G2/M where it docks to phosphorylated Bub1 and the PBD-binding p-T78 motif on its own T-loop to auto-activate, then successively phosphorylates Cdc25C, Cyclin B1, Wee1, APC/C-Cdc20, and myriad kinetochore proteins to drive centrosome maturation, bipolar spindle assembly, chromosome alignment, the spindle-assembly and decatenation checkpoints, and timely mitotic exit, while its deregulated overexpression in cancers creates chromosomal instability and chemoresistance, making it a high-priority drug target whose ATP-competitive inhibitors (BI 2536, volasertib) are already in oncology trials.

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SKU: 47298270151

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4.7 ★★★★★
Based on 247 reviews
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Product Reviews
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Verified Purchase
William L. Pogue
Waukegan, US
★★★★★ 5
Five Stars
Format: Paperback
good job
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on July 5, 2018
M
Michael Griswold
Chelsea, US
★★★★★ 4
A Book For Audio
Format: Audiobook
The Art of Storytelling from Parents to Professionals is the first book that I can be confident in saying is better as an audio version than it would be in a paper or Kindle form because you can here the verbal inflections and the storytellers can change character, voice much easier than the printed word might. It also captures the listeners attention as the author herself can connect in a lot more personal and intimate way. My concern is while I can understand what the author is getting at, I am not aspiring to be an oral performance style storyteller and there was not enough of a reach out from the world of oral storytelling to the written story. I mean how many of us are going to get up on stage and tell stories? I guess you can take the skills from one realm and use them elsewhere, but the connection may not be made so easily. This was an audiobook that I had a lot of fun with, even if I didn’t quite get what I was hoping for from it.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on July 10, 2020
L
Louis LaSalle
Natrona Heights, US
★★★★★ 5
Great Overview of the Art of Storytelling
Format: Audiobook
I chanced on this as an Audible "freebie" to keep on the list for when I was out of credits. Well, it's excellent, and well worth the listen. And excellent survey of the topic spanning topics of performance (preparing, voice, body language, projection), various aspects of framing (culture, age, ethnicity, audience size), story structure and so on This point is for Hannah B. Harvey, if perchance she reads tese reviews. One point of modern storytelling and writing that is not brought out in your lectures, is that some of the best villain/antagonists are actually the heroes/protagonists of their own stories. This is tangentially alluded to in talking about story viewpoints, but not to the extent that it can be an entirely new story, as Wicked and Maleificent turned The Wizard of Oz and Sleeping Beauty on their heads. And even in the 1960's, many a Bond 007 villain was trying to create what they imagined to be a better world. It's useful to consider in storytelling, as far too many people have forgotten/fail to see the fundamental moral ambiguities of life, and I suspect that goes a long way to explaining the extreme partisanship we see in the world today.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on September 17, 2023
D
Doodlebugs
Bozeman, US
★★★★★ 3
Sadly, I found the tips and the examples in this lecture to be very simplistic and uninspiring.
Format: Audiobook
I expected a professional storyteller to be able to keep my interest but I found the presentation to be quite boring. I got nothing out of it that I didn’t already know from just being an avid reader. It felt like a high school lecture. Sigh!!
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on July 15, 2019
E
Emilia Taneva
Dallas, US
★★★★★ 5
Great course on how to improve your storytelling abilities
Format: Audiobook
Storytelling is a great way to get a point across, and most of us digest information through stories. But when it comes time to tell a story, most of us don't have the skills to make the story engaging or impactful. That's where this course on storytelling comes in. You'll get good pointers on vocabulary, body language, tone, along with deeper pointers about how to shape the view of the story and how to refine its characters. It's all very detailed but it's all very interesting and well worth it. This course will help you see how useful storytelling can be in your personal and professional life, especially if you're in a field where you have to do a lot of public speaking.
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Reviewed in the United States on August 21, 2021

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