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Description
Human & Monkey CCL5 /RANTES Onestep ELISA KitProduct Specification Antigen CCL5 (RANTES) Immunogen Recombinant Protein Antibody Type Recombinant mAb Purification Protein A Stability & Storage 12 months from date of receipt reconstitution, 2 to 8'C as supplied. Kit Precision Intra assay: 4. 0% Inter assay: 4. 8% Sample type Cell culture supernatant; Serum; Plasma Assay type Sandwich (quantitative) Sensitivity 1. 017 pg mL Range 4. 69 pg mL 300 pg mL Recovery Cell culture supernatant: 91% Serum:
Product Specification
| Antigen | CCL5 (RANTES) |
| Immunogen | Recombinant Protein |
| Antibody Type | Recombinant mAb |
| Purification | Protein A |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8'C as supplied. |
Kit
| Precision | Intra-assay: 4.0%； Inter-assay: 4.8% |
| Sample type | Cell culture supernatant; Serum; Plasma |
| Assay type | Sandwich (quantitative) |
| Sensitivity | 1.017 pg/mL |
| Range | 4.69 pg/mL – 300 pg/mL |
| Recovery | Cell culture supernatant: 91% Serum: 90% Plasma: 82% |
| Assay time | 60 minutes |
| Species reactivity | Hu; Mk |
Background
Human CCL5 (CC Chemokine Ligand 5), previously known as RANTES (Regulated upon Activation, Normal T-cell Expressed and Secreted), is a pivotal member of the CC chemokine family characterized by its role in orchestrating immune cell migration and activation. This 8-kDa protein is secreted by a variety of cells, including T lymphocytes, platelets, macrophages, and endothelial cells, in response to inflammatory stimuli. CCL5 exerts its biological functions by binding to and signaling through multiple G-protein coupled receptors, primarily CCR1, CCR3, and CCR5. Its primary role involves the selective chemoattraction of leukocytes—such as T cells, eosinophils, basophils, and monocytes—to sites of inflammation or infection, thereby playing a critical role in both innate and adaptive immune responses. Furthermore, CCL5 is implicated in the pathogenesis of a spectrum of diseases, including autoimmune disorders, chronic inflammatory conditions, and HIV-1 infection, as it also acts as a natural ligand for CCR5, a major co-receptor for viral entry. Consequently, the CCL5-CCR5 axis represents a significant therapeutic target for immunomodulation.
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