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Description
Stat5 Recombinant Rabbit mAb (S-2823-24)Product Specification Host Rabbit Antigen STAT5 Synonyms Signal transducer and activator of transcription 5B; STAT5B Immunogen Recombinant Protein Location Cytoplasm, Nucleus Accession P51692 Clone Number S 2823 24 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P Reactivity Hu, Ms, Rt, Mk Positive Sample K562, HDLM 2, Raji, HeLa, Jurkat, A20, mouse heart, PC 12, COS 7 Purification Protein A Concentration 0. 5 mg ml Conjugation
Product Specification
| Host | Rabbit |
| Antigen | STAT5 |
| Synonyms | Signal transducer and activator of transcription 5B; STAT5B |
| Immunogen | Recombinant Protein |
| Location | Cytoplasm, Nucleus |
| Accession | P51692 |
| Clone Number | S-2823-24 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P |
| Reactivity | Hu, Ms, Rt, Mk |
| Positive Sample | K562, HDLM-2, Raji, HeLa, Jurkat, A20, mouse heart, PC-12, COS-7 |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu, Ms, Rt, Mk |
| IHC-P | 1:50-1:200 | Hu, Ms, Rt |
Background
Stat5 (Signal Transducer and Activator of Transcription 5) is a latent cytoplasmic transcription factor that becomes phosphorylated on a conserved tyrosine (Tyr694 in human STAT5a) by activated Janus kinases—primarily JAK2—following cytokine (e.g., IL-2, IL-3, GM-CSF, GH, PRL, EPO, TPO) or oncogenic tyrosine-kinase receptor (e.g., BCR-ABL, FLT3-ITD, JAK2V617F) signaling, whereupon it forms parallel homo- or heterodimers, translocates into the nucleus, binds the consensus DNA motif TTCNNNGAA within enhancers/promoters of target genes like CISH, BCL2, MYC, CCND1, PIM1 and SOCS proteins, and thereby orchestrates proliferation, survival, self-renewal and differentiation programs in hematopoietic, mammary and other cell types; persistent Stat5 activation is a driver of myeloproliferative neoplasms, acute leukemias and breast cancers, making its upstream kinases and the Stat5 SH2 or DNA-binding domains attractive therapeutic targets.
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